Dutchwoman Marlou van Rhijn became the fastest ever female leg amputee at the IPC Athletics Grand Prix in Berlin.
Already 100m world record holder for double leg amputees, her time of 12.96 seconds was 0.02 faster than the T44 mark for single leg amputees set by April Holmes of the US in 2006.
The 21-year-old also took 3.85secs off her 400m world record, setting a new mark of one minute 0.10s.
Brazilian Alan Oliveira broke the men's 100m record at the same meeting.
The 20-year-old double amputee set a time of 10.77 - 0.14 faster than the mark set by South African T43 spinter Oscar Pistorius in April 2007 which had been equalled by Blake Leeper of the United States in July 2012.
It is also 0.08 seconds faster than the 100m T44 record held by Jonnie Peacock.
Oliveira could only finish seventh in the 100m T44 final at the Olympic Stadium in September as the 20-year-old Briton took gold.
The pair will face each other again at July's IPC World Championships in Lyon, with American Richard Browne, who last weekend unofficially equalled Peacock's best of 10.85 seconds, also set to line up against them.
Record holder: Alan Oliveira in action at the London Olympics
Oliveira beat Oscar Pistorius to gold in the T43/44 200m at London 2012, which prompted the South African athlete to complain about the length of his opponent's blades.
Van Rhijn, who won 200m gold at the London Paralympics, tweeted of her achievement: "So happy to say that I'm now the fastest woman ever on (1 or 2) blades!"
The T43 category includes double below-the-knee amputees and other athletes with impairments deemed equivalent, while the T44 category is for those athletes who are single below-the-knee amputees and equivalent impairments.