Manchester United manager David Moyes has been sacked, only 10 months after succeeding Sir Alex Ferguson.
He was dismissed at a meeting with executive vice-chairman Ed Woodward at the club's Carrington training ground shortly after 0800 BST.
Moyes, 50, was chosen by Ferguson as the man to succeed him when he retired after 26 years in charge last summer.
Player-coach Ryan Giggs is expected to take charge of United's next game at home against Norwich on Saturday.
The BBC understands coaches Steve Round and Jimmy Lumsden have also left their posts.
The club had previously refused to comment on national newspaper reports on Monday that Moyes - who left Everton to sign a six-year deal with the Premier League champions - would be dismissed before the end of the season.
But in a statement on Tuesday the club said it "would like to place on record its thanks for the hard work, honesty and integrity he brought to the role".
Netherlands coach Louis Van Gaal, Borussia Dortmund boss Jurgen Klopp, Atletico Madrid's manager Diego Simeone and Paris Saint-Germain's Laurent Blanc have already been tipped as possible successors to Moyes.
United, who currently lie seventh in the table with four games remaining, are guaranteed to record their lowest ever points tally in the Premier League having struggled at Old Trafford in particular this season.
Under Moyes, they have lost six league games at home, been beaten in the FA Cup by Swansea at Old Trafford and were unable to prevent Sunderland knocking them out of the Capital One Cup in the semi-finals.
In March, some supporters chartered a plane to fly overhead trailing a banner with the words "Wrong One - Moyes Out" - a reference to the banner at Old Trafford that proclaimed Moyes to be the "Chosen One" - during the Premier League win over Aston Villa.
The Reds will also miss out on Champions League football for the first time since 1995 and are in danger of missing out on European competition altogether for the first time since 1990.
United did reach the last eight of the Champions League before being knocked out by Bayern Munich and Moyes argued that their best displays had been in the competition.
But the Scot has been dogged by claims he has fallen out with members of his squad.
When midfielder Anderson joined Fiorentina on loan in January, he was quoted as saying other United players "wanted out" although he later denied it.
David Moyes' exit was inevitable after Sunday's awful
performance at Everton.
A dressing room source labelled the performance as
"lacking desire and passion" and "the basic heart of the
team has disappeared". It had seemed for some time the
players had stopped trying for Moyes. This confirmed it.
In truth, the Scot has never looked at ease in the job.
He was taken aback by the sheer scale of the media
interest in United. He downplayed situations when the
club are used to scaling heights and he failed to impress
players who own more medals than he can ever hope to
The big problem for United is that having taken Sir Alex
Ferguson's word on the appointment, who do they turn
At the weekend, Manchester-born striker Danny Welbeck was reported to be considering his future after becoming frustrated at regularly being played out of his favoured position.
Moyes left Everton after 11 seasons saying he could not turn down the opportunity to move to Old Trafford and began his job on 1 July.
A double bid for Marouane Fellaini and Leighton Baines was dismissed as "derisory and insulting" by Moyes' old club Everton, although Fellaini finally joined on transfer deadline day for £27.5m.
Moyes was unhappy United were given a difficult start to the season, playing Chelsea, Liverpool and Manchester City in their first five games.
"I find it hard to believe that's the way the balls came out of the bag, that's for sure," he said.
However, things quickly got worse with defeats at Liverpool and City, setting the tone for what would become United's worst ever Premier League season.
With the exception of Matt Busby's additional 21 games in charge as emergency manager following Wilf McGuinness' exit in 1970 and the 22 games when Jimmy Murphy stood in for Busby after the Munich crash, Moyes' reign represents the third shortest in United history.
It is also the first time since 6 November 1986, that Manchester United have sacked a manager.
The Scot's 49 games in charge exceeds only the 43 matches Walter Crickmer presided over during the first of his two spells as manager. Lal Hilditch was in charge for the least time, lasting just 33 games between October 1926 and April 1927.