DJ Tim Westwood is leaving BBC Radio 1 and 1Xtra as part of a schedule update.
His Saturday night show, which is currently broadcast simultaneously on Radio 1 and 1Xtra at 9pm, is being cut.
The new line-up will start with MistaJam at 7pm, followed by Charlie Sloth at 9pm and DJ Target at 11pm.
Radio 1 and 1Xtra controller Ben Cooper said: "I'd like to thank Tim for the last 20 years on Radio 1 - his passion for hip-hop is legendary. I wish him all the very best."
"It's like a dream come true for me and
something that I've worked towards my
whole career, especially to be
succeeding a legend like Tim Westwood"
Radio 1Xtra DJ
Throughout his career he has won a variety of awards including five Mobos for best DJ.
The 55-year-old began his career at Radio 1 in 1994 hosting the station's first rap show.
He was injured in a drive-by shooting in south London in 1999 after gunmen opened fire on his car.
The DJ was criticised in 2006 by then leader of the opposition, David Cameron, who accused the DJ of encouraging knife and gun crime.
The changes to the Radio 1Xtra schedule will take effect from 21 September.
Speaking about his new show MistaJam said: "It's an absolute honour to be given the chance to lead the 1Xtra takeover of Radio 1 on a Saturday night. I've grown up listening to Trevor Nelson and he's still at the top of his game so it's a dream come true."
DJ Target, Charlie Sloth, MistaJam and Clara Amfo have new shows
Charlie Sloth joined Radio 1Xtra in 2010. In 2012 he replaced Westwood in the weekday drive time show from 4 to 7pm.
In 2013, Charlie Sloth was nominated for two Sony Radio Academy Awards for best entertainment programme and music personality of the year.
"Words can't describe how happy I am," he said.
"It's like a dream come true for me and something that I've worked towards my whole career, especially to be succeeding a legend like Tim Westwood who has done so much for the game.
"I know they are big shoes to fill, but luckily, man's got fat feet."
New signing Clara Amfo says she is "absolutely delighted" to become the host of the weekend breakfast show on BBC Radio 1Xtra.
At the moment Trevor Nelson hosts a show from 7pm on Saturday nights.
Although he will not continue in that slot, he has renewed his contract to present his weekday show on 1Xtra and will still be presenting his Wednesday night soul show on Radio 2.