Marchers found a firm police presence in the city centre
More than 1,000 protesters have marched in Baltimore over the death of a black man in police custody a week ago.
A minority of protesters smashed police car windows and at least a dozen were arrested, after disturbances that led police to delay spectators' departure from a baseball game.
Freddie Gray was arrested by police on 12 April and then suffered spinal injuries leading to death a week later.
His twin sister, Fredricka Gray, appealed for calm.
As clashes began on Saturday evening, she said: "My family wants to say, can you all please, please stop the violence?
"Freddie Gray would not want this."
Six police officers have been suspended following the death and an internal police investigation is under way.
Gray, who was 25, is the latest of a series of black Americans to die in police custody in recent months, triggering angry protests accusing the police of brutality.
Baltimore has seen daily protests since his death on Sunday but Saturday's was expected to be the largest so far.
One of Saturday's rallies, organised by the People's Power Assembly, made its way from the Sandtown neighbourhood where Gray was arrested to the Western District police station where an ambulance was called for Gray once he arrived in a police van, injured.
Another rally, called by Black Lawyers for Justice and other groups, congregated outside City Hall.
Protesters lay on the street to block traffic
"It cannot be business as usual with that man's spine broken," said Malik Shabazz of Black Lawyers for Justice
"Things will change on Saturday, and the struggle will be amplified," Malik Shabazz of Black Lawyers for Justice told WBAL-TV Baltimore. before the march began. "It cannot be business as usual with that man's spine broken, with his back broken, with no justice on the scene."
However, in the evening some demonstrators started to smash shop windows and there were some fights with baseball fans before the game between the Baltimore Orioles and the Boston Red Sox.
Police Commissioner Anthony Batts admitted at a news conference on Friday that officers repeatedly failed to give Gray the medical attention he was due and that, contrary to policy, Gray was not strapped into his seat in the police van following his arrest.
The police will report the findings of their investigation on 1 May, when protesters hope the six suspended police officers will be charged - and have vowed further protests if they are not.
An independent review by state prosecutors will follow.
But the police officers' union has criticised Commissioner Batts' comments about failures in the treatment of Freddie Gray, saying they were "politically driven" and premature.